Headquartered in downtown St. Louis at the intersection of Fourth, St. Charles and Broadway, the Federal Reserve Bank of St. Louis takes great pride in serving "Main Street" audiences and representing their views. The St. Louis Fed is located in the Eighth Federal Reserve District and is a part of the Federal Reserve central bank system that's composed of 12 independent regional Reserve banks and the Board of Governors in Washington, D.C.

The Eighth Federal Reserve District includes all of Arkansas and portions of six other states: Illinois, Indiana, Kentucky, Mississippi, Missouri and Tennessee. The St. Louis Bank serves most of eastern Missouri and southern Illinois.